Help us build the future of science education!

Substrate Games is reimagining how traditionally challenging health-focused science concepts are learned and taught. Using a game-based approach, we’re focused on building engaging, accessible, and effective products that students and their instructors genuinely love. Our initial focus is on expanding our organic chemistry prototype to tackle a notorious “weed out” course. With the support of both the National Institutes of Health and leading educational institutions, we are well-positioned to impact millions college students in a fast-growing $170B+ market.


Lead Chemist

Remote (US-Only) | Full-Time

We’re looking for a Lead Chemist to help us build exciting new mobile software for teaching and learning organic chemistry. In this dynamic role you’ll wear multiple hats across development, communication, and customer success. The ideal Lead Chemist will have strong domain knowledge, experience with computational chemistry, and a genuine enthusiasm for communicating complex science concepts.

Learn more.


  • Help improve the learning experience for potentially millions of students.

  • Work with a nimble, mission-driven team.

  • Compensation package including salary, stock options, PTO, and 401k match.

  • Generous healthcare coverage including medical, dental, vision, life and long-term disability insurance.

  • Live where you choose and work remotely.

  • Opportunities for personal learning, professional development, and travel.