Help us build the future of science education!

Substrate Games is reimagining how traditionally challenging health-focused science concepts are learned and taught. Using a game-based approach, we’re focused on building engaging, accessible, and effective products that students and their instructors genuinely love. Our initial focus is on expanding our organic chemistry prototype to tackle a notorious “weed out” course. With the support of both the National Institutes of Health and leading educational institutions, we are well-positioned to impact millions college students in a fast-growing $170B+ market.



Des Moines, IA | Full-Time

We’re seeking a Chief Technology Officer to join our executive team and help us build the next-generation of tools for science education. As CTO, you’ll have great responsibility and influence over our engineering efforts, whether that’s building out our core technologies, developing product, or aligning with business strategy. The ideal candidate is a strong individual contributor capable of tackling any technical challenge across the full technology stack, but can also lead and mentor a small development team. Your contributions to our mobile interactive learning platform have the potential to improve the learning experience for millions of students.

Learn more.


Lead Chemist

Des Moines, IA | Full-Time

We’re looking for a Lead Chemist to help us build exciting new mobile software for teaching and learning organic chemistry. In this dynamic role you’ll wear multiple hats across development, communication, and customer success. The ideal Lead Chemist will have strong domain knowledge, experience with computational chemistry, and a genuine enthusiasm for communicating complex science concepts.

Learn more.


Lead Designer

Des Moines, IA | Full-Time

We’re looking for a Lead Designer to join us in building the future of science education tools. This diverse role will span the product design process from initial user research, assembling prototypes, and building visual assets, to guiding the final implementation of your solutions. The ideal Lead Designer will be a strong creative who can empathize with our users and build outstanding product features that solve real needs.

Learn more.


  • Help improve the learning experience for potentially millions of students.

  • Work with a nimble, mission-driven team.

  • Compensation package including salary, equity, PTO, and 401k match.

  • Generous healthcare coverage including medical, dental, vision, life and long-term disability insurance.

  • Opportunities for personal learning and professional development.


Substrate Games is headquartered in the heart of Des Moines, Iowa, which enjoys a rapidly developing entrepreneurial ecosystem. Thanks to a low cost of living and high quality of life, Des Moines is frequently featured as a top place to live for young professionals and growing families. Here you’ll find the ability to own a home, commute to work in less than 20 minutes, and enjoy a friendly and welcoming community of smart, hard working people. Des Moines is home to nationally recognized events including the Des Moines Art Festival and the Iowa State Fair, as well as numerous locations for hiking, biking, and more. If that’s not enough, Omaha, the Twin Cities, Kansas City, and Chicago are just a weekend trip away.

Substrate Games is an equal opportunity employer.